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Hashimoto K, ed

Understanding the Cold Chain Needs of GLP-1 Drugs GLP-1 drugs are biologically active medications that require cold chain shipping due to their sensitivity to temperature fluctuations

The mice were intracardially perfused with phosphate-buffered saline (PBS) followed by cold 4% paraformaldehyde (PFA) in PBS

Bipolar disorder and immune dysfunction: epidemiological findings, proposed pathophysiology and clinical implications

The superior cardioprotective effect of GLP-1 (7-36amide) relative to exendin-4 and the preservation of efficacy of GLP-1 (7-36amide) but not exendin-4 in GLP-1R KO mice suggest that some of the cardioprotective effects of GLP-1 (7-36amide) are independent of GLP-1R signaling and are potentially mediated via the DPP-4-cleaved GLP-1 metabolite GLP-1 (9-36amide) [201]

Despite numerous studies, the causes of the obesity epidemic are still not fully understood, and traditional calorie-restricted diets still lack long-term effects ( Besides lowering blood glucose and reducing weight (incredibly visceral fat), GLP-1R agonists can also lower blood pressure, improve blood lipid disorder, and reduce fatty liver ( Given that GLP-1R agonists have superior weight loss effects and good safety, some of its products have been officially approved by FDA for chronic weight management of obese or overweight adults