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The EMPA-KIDNEY trial enrolled a larger proportion of participants without diabetes mellitus and included individuals with lower mean eGFR (37.3 mL/min/1.73 m) and median UACR (329 mg/g) compared to DAPA-CKD

As such, glomerular lesions occur which include glomerular basement membrane thickening, podocyte effacement and loss, mesangial expansion, epithelialmesenchymal transition EMT and fibrosis, collagen deposition, damage to the capillary architecture and an influx of inflammatory cells including macrophages

Both groups tolerated the drinks about the same

Many employers recognized that these drugs could have beneficial health impacts for their workforce, although they disagreed about the extent to which these drugs would reduce other healthcare use or provide a return on their investment