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This establishes a baseline of muscle stimulus and neural adaptation, making it easier to maintain intensity as appetite suppression increases

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Supply of GLP-1 medicines has been uneven at times

Retatrutide dosage escalation (Phase 2 trial protocol) The Phase 2 trial tested multiple starting dose strategies

[1] Licensed pharmacological options in the UK include orlistat (available at BMI 30 kg/m, or 28 kg/m with weight-related risk factors) and semaglutide (available within specialist weight management services as per NICE TA875, with adjusted BMI thresholds for some ethnic groups)