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The case of Eli Lillys tirzepatide suggests we may be approaching a ceiling in terms of efficacy: aiming for weight loss beyond 20% might be neither necessary nor clinically sound

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GLP-1 receptor agonist sales growth rates are around 50% a year for diabetes treatment, but much higher for the new classes of obesity-optimised GLP-1 receptor agonists

These include nausea, vomiting, diarrhoea, and constipation, most of which were mild to moderate in severity and occurred most frequently during dose escalation [8]