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The Future of MOTS-c Research Clinical trials for MOTS-c have begun, which will eventually provide the human data currently lacking

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Semaglutide (Ozempic/Wegovy) targets GLP-1 receptors to suppress appetite and improve metabolic function, while tirzepatide (Zepbound) takes treatment a step further with a dual-action mechanism that activates both GLP-1 and GIP receptors simultaneously

-Surveillance data (e.g., Australias TGA) show dozens of reports of eye disorders in people using semaglutide (including optic ischaemic neuropathy, blindness/visual impairment) though these are spontaneous reports, so causality is uncertain