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Chronic activation of microglia is associated with protein degradation, mitochondria dysfunction, and defects of axonal transport and apoptosis, which adversely affect neuronal function and lead to cell death (49)

30 The FDA, more generally, should take a more active role in working with the USPTO to ensure that patents submitted for listing in the Orange Book have been validly granted and are not overly broad

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Available from: www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss [Last accessed: December 31, 2023]

[DOI] [PubMed] [Google Scholar] Dillon JS, Lu M, Bowen S, Homan LL