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(2023, March 14)

Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Published in Cardiovascular Diabetology Endocrinology Reports , the study pooled data from more than 90,000 patients across 11 clinical trials and found about a 13 percent reduction in major cardiovascular events over nearly three years

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Statins and diuretics may be used in patients with T2D for the management of dyslipidemia and hypertension, respectively