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Yet pre-existing leptin receptor resistance often persists, creating a physiological environment that actively resists further weight loss
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Typical GLP tolerance and side effect profile These efficacy results approach those seen with weekly injectable formulations , even though oral delivery historically posed challenges due to absorption limitations in the gut
As of 2022, GLP-1RAs have been recommended as first-line treatments, along with SGLT-2 inhibitors, for patients with T2DM and cardiovascular disease in American Diabetes Associations Standards of Medical Care in Diabetes (248, 249)
