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Thus, semaglutide likely contributes to immunometabolic remodeling of adipose tissue by reducing macrophage-mediated inflammation, shifting the macrophage phenotype toward the M2 (anti-inflammatory) state, and suppressing key inflammatory signaling pathways

Based on typical review timelines, analysts project a potential approval in late 2026 or 2027

GLP-1 RA therapy can continue in parallel with psychological care, as both target distinct but interacting domains [46]
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Counsel patients about protective measures, including the prevention of transmission of human immunodeficiency virus (HIV) infection, as appropriate to the individual circumstances
