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![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

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evidence from uncontrolled designs (case reports, case series, pharmacovigilance analyses) was initially rated very low certainty, as these designs are inherently uncontrolled and start below the lowest GRADE tier

When oxidative demand approaches the regenerative capacity of nicotinamide adenine dinucleotide (NAD)/ nicotinamide adenine dinucleotide phosphate (NADPH

Clostridium butyricum produces the postbiotic butyrate which stimulates GLP-1. Bifidobacterium infantis produces the postbiotic acetate, and interacts with Akkermansia and Butyricum to promote an ecosystem in the gut that naturally boosts GLP-1