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Abnormalities in these organs can also cause fatigue, he says

This may partly explain why tirzepatide produces greater weight loss than its GLP-1 potency alone would predict, and why it shows superior glycemic outcomes in type 2 diabetes compared to semaglutide in head-to-head trials

High glucose levels stimulate hepatic LEAP2 production and secretion [157], and LEAP2 infusion lowers postprandial plasma glucose and GH concentrations [178] while enhancing insulin secretion [59]

This reduced motility is medically termed delayed gastric emptying or gastric stasis

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