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PRLR knockout (Prlr-) mice developed impaired glucose tolerance, decreased insulin secretion, a 20-35% reduction in islet insulin granules, reduced islet density and reduced -cell mass

Gcg = glucagon

Healthcare professionals and trial participants should be aware of the following: Always follow the storage instructions on the IMP label and those provided by the trial site pharmacist these are the definitive reference Report any storage deviations (such as accidental freezing or heat exposure) to the trial team promptly

& Montague, P

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Discussion The introduction of new GLP-1 receptor agonist drugs results in better treatment of diabetes and obesity, but also in a potential risk of inducing new adverse reactions that have not yet been properly described [9]