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However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment

Semaglutide is available in both injectable and oral forms, while liraglutide comes in injectable form only

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Diabetes in pregnancy: management from preconception to the postnatal period Recommendations (NG3)