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Clinical trial data shows weight regain typically begins within 6 to 12 months of complete discontinuation, supporting ongoing maintenance rather than stopping entirely

GLP-1 analogues are generally not recommended during pregnancy or breastfeeding due to limited safety data in these populations

Cardiometabolic benefits Both tirzepatide and retatrutide have demonstrated improvements in various cardiometabolic risk factors, such as blood pressure, lipid profiles, and glycemic control

It mimics the natural GLP-1 hormone thats released in the gut after eating, helping regulate both blood sugar and appetite

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