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This is in partial contrast to a study that found an increase in PSD95 in the hippocampus of male mice after GLP-1 receptor agonist treatment (99) in 5XFAD mice (a mouse model of Alzheimers disease), but not young, male wild-type young male mice

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However, given the widespread use of the drugs, which some estimates suggest have been prescribed to about 12% of the U.S

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