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By the end of the week, appetite is down, nausea is up, and it is suddenly clear that eating well on this medication is less about willpower and more about choosing foods that match what your body can tolerate

Enhanced Gut Health GLP-1 influences gut motility and microbiome balance

Enhanced metabolic flexibility
Tirzepatide in type 1 diabetes: single-centre observational cohort (N=26), 2025

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It stimulates insulin release in a glucose-dependent manner so that hypoglycaemia does not occur (the incretin effect) and it suppresses glucagon secretion, actions which inhibit hepatic gluconeogenesis
