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They target different receptors (two versus three), have different pharmacokinetics, and produce different metabolic effects per milligram
Liraglutide 3.0 mg reduced BMI by 4.3% over 56 weeks in adolescents with obesity, while placebo reduced BMI by 0.3% in the long term [115]
Tirzepatide at all doses showed higher efficacy than semaglutide
Tirzepatide is a benchmark compound
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