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LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet alSemaglutide and cardiovascular outcomes in obesity without diabetes

GLP-1RAs: Beyond glycemic control GLP-1RAs such as semaglutide and the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RAs tirzepatide enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through central pathways

The researchers also found reduced responses to GLP-1 in both the pancreas and the gut, even though the number of GLP-1 receptors in these tissues remained unchanged

Peak plasma concentrations (C max ), time to C max (t max ) and area under the plasma concentration versus time curve for the last measurable plasma concentration (AUC 0last ) were calculated using noncompartmental methods

YZ: Writing original draft, Supervision, Data curation, Formal analysis

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