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Some patients use weight loss treatments for a defined period, while others may require longer-term therapy based on medical evaluation and response

N Engl J Med (2021) 385:896907

A total of 670 eligible participants were randomly assigned to either continue taking Zepbound for an additional year (52 weeks) or to switch to a placebo

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In contrast, SEMA showed a gradual but oscillatory weight loss which fluctuated between 16 and 20% of initial weight which remained stable until endpoint (Fig