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Selection strategy of dextran sulfate sodium-induced acute or chronic colitis mouse models based on gut microbial profile

Techniques such as liquid chromatographymass spectrometry (LC-MS), direct infusion mass spectrometry, proximity extension assays (Olink), and aptamer-based assays (SomaScan) enable detection of multidimensional biomarker patterns linked to atherosclerosis progression ( Key findings include identification of lipid species such as ceramides, sphingolipids, and glycerolipids that strongly correlate with atherosclerosis progression and cardiovascular events ( Importantly, these platforms provide a scalable approach to evaluate vascular molecular responses to therapies

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1 As the medical community continues to seek effective strategies to reduce the global burden of stroke, GLP-1 RAs offer a promising avenue that warrants further exploration and broader implementation in clinical practice

The mean calorie intake was 1,748 kcal/day for the overall sample, 1,700 kcal/day for females, and 1,933 kcal/day for males

This approach may improve compliance and reduce side effects compared to one-size-fits-all dosing, particularly for patients with metabolic complexity or prior medication sensitivities