glp 1 drugs and addiction IUPHAR review – Glucagon-like peptide-1 (GLP-1) substance use disorders: An emerging pharmacotherapeutic target GLP-1 Receptor Agonists and Research

Description

Common Side Effects Both medications cause primarily gastrointestinal effects: Saxenda common side effects: Nausea (39%) Diarrhea (21%) Constipation (19%) Vomiting (16%) Injection site reactions (14%) Headache (14%) Dyspepsia (10%) Semaglutide common side effects: Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (24%) Abdominal pain (20%) Headache (14%) Fatigue (11%) Side Effect Comparison Table Interpreting the Numbers Semaglutide appears to have higher rates of GI side effects in clinical trials

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To fully elucidate the physiological roles of gut-derived GLP-1, further investigation is needed into the function of GLP-1 receptor-expressing vagal sensory nerves

For individuals performing regular resistance or strength training , higher protein intakes of 1.62.2 g/kg/day ( 0.71.0 g/lb/day) may further enhance muscle growth, repair, and recovery , particularly when total calories are reduced