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doi: 10.3724/SP.J.1009.2016.00017 129 ZhangMChenMZhangH-QSunSXiaBWuF-H

1).29,32 With respect to the vascular system, rGLP-1 activation induces modest decreases in blood pressure,33,34 it has a vasodilator effect, improves arterial stiffness, and prevents atherosclerotic plaque formation-and has plaque stabilizing effects-through its anti-inflammatory and antiapoptotic effects as demonstrated in animal models.29,32,3538 Despite controversies about rGLP-1 expression in vascular smooth muscle and endothelial cells, studies have shown that arGLP-1 has antiproliferative effects on these cells,39 reduces oxidative stress, improves endothelial function, and increases nitric oxide production in experimental models.3540 In the heart they produce a discrete increase in heart rate (24 beats/min), although this does not seem to be associated with an increase in arrhythmias or cardiovascular events

Researchers compared the percentage of body weight loss after 3, 6, 9 and 12 months of treatment among adults who received intensive lifestyle modification, non-GLP-1 receptor agonist pharmacotherapy or GLP-1 receptor agonists as part of a weight-loss program, with both pharmacotherapy groups also utilizing intensive lifestyle modification

Some alternatives for treating type 2 diabetes include Mounjaro (tirzepatide) and Trulicity (dulaglutide), and others for chronic weight management include Wegovy (semaglutide) and Zepbound (tirzepatide)

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[1] Unsupervised microdosing without appropriate medical oversight could lead to inadequate treatment