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Circulation 149 , 450462

Unlike semaglutide and tirzepatide, where the FDA has now spent years responding to shortages, compounding, and illicit imports, many of these newer drugs are still investigational

44,45 In response to overnutrition, obesity and insulin resistance, beta-cells adapt by increasing their mass and/or number, both of which result in increased capacity of insulin secretion

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Brain Sci
