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Instead, your healthcare team may recommend maintaining both medications while monitoring for unusual bruising, bleeding gums, or blood in stool

Dr Rohana said common gastrointestinal side effects include nausea, vomiting, constipation, or diarrhoea, which are typically self-limiting and subside within one to two weeks

doi: 10.1038/nrneurol.2017.185

This could be one reason why some people experience leg cramps when using semaglutide