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6 Oct 2022 Hannah Beba, Clair Ranns, Clare Hambling, Jane Diggle, Pam Brown Vol:24 | No:05 Page: 147 Publishers note: The advice in this consensus is now out of date

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Studies have shown that reduced function of plasma membrane monoamine transporter or organic cation transporter 1 leads to an increase in metformin GI side effects (72,73)

A 132-patent portfolio means 132 separate analyses, certifications, and potential litigation tracks a workload that can require years of due diligence and tens of millions in legal fees before a single trial commences

The winner will depend on Phase 3 data, tolerability, approval timing, label breadth, payer access, and real-world persistence