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No large prospective trial specifically addresses GLP-1 RA-plus-meglitinide combinations, but the pharmacologic rationale is identical to sulfonylureas

( 10.1161/CIRCULATIONAHA.117.028136) [DOI] [PubMed] [Google Scholar] Nauck MA Quast DR Wefers J & Meier JJ

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Thus, the GLP-1 WT albiglutide-mimic and GLP-1 QMP fusions engaged the human GLP-1R expressed by the cells, although at a lower potency than unfused GLP-1, which is in line with previous reports on albiglutide/Tanzeum and other GLP-1 fusion proteins 10,76,77

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