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In these settings, glucose dysregulation, visceral adiposity, fatty liver, vascular inflammation, and chronic low-grade inflammation often reinforce one another, creating a cascade of metabolic stress that accelerates functional decline

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Of those 161 patients, 16 (10%) experienced recurrent acute pancreatitis after GLP-1 receptor agonist therapy (mean duration 10.8 7.2 months): 6 (38%) were caused by the GLP-1 receptor agonist (as clinically determined by the treating medical team), three (18%) were due to hypertriglyceridemia, two (12%) due to alcohol use, one (6%) due to another oral hypoglycemic agent, one (6%) due to ampulla stenosis, and three (19%) were idiopathic

Pediatr Res (2013) 74(4):4206.10.1038/pr.2013.114 158 KarraschTObermeierFStraubRH