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GLP-1RA in Diabetes and Diabetic Kidney Disease GLP-1RAs represent an advanced therapeutic option for type 2 DM, particularly in patients with concomitant cardiovascular and renal comorbidities

Other serious side effects are kidney failure, pancreatitis, and gallbladder problems

adults have obesity, defined by a body mass index (BMI) of 30 or higher

Because coadministration of a high-fat meal with JANUVIA had no effect on the pharmacokinetics, JANUVIA may be administered with or without food

cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

D., Huynh, K., & et al