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the STEP 5 trial represents the most extensive study on the use of semaglutide for weight management to date

In general, patients should be cautious when considering compounded forms of GLP-1 drugs

By reducing the inflammatory load of adipose tissue, weight loss and adipokine normalization may therefore represent an indirect but clinically meaningful mechanism by which GLP-1RAs influence thyroid autoimmunity

According to the FDA, these salt forms should not be used for compounding because they are not the same as semaglutide base and have not been shown to be safe or effective

Many patients taking GLP-1 receptor agonists also use other medications that may affect fluid balance, including diuretics or SGLT2 inhibitors