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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Knudsen LB, Nielsen PF, Huusfeldt PO, Johansen NL, Madsen K, Pedersen FZ, et al

In SURMOUNT-2, the mean WL was up to 15.7% with tirzepatide 15 mg compared to 3.3% WL with placebo at 72 weeks for people with obesity and T2D [47]

Discussion The intestinal epithelial barrier is usually the first site to be involved in the inflammatory conditions affecting the gut, 24 where microorganisms or allergens are first encountered, leading to activation of the local immune cells and recruitment of new immune cells which alter the local environment resulting in the major hallmarks of inflammation

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Let's examine the evidence to understand the potential synergy between these two powerful therapies

Special considerations in older adults Ruchi Gaba, MD, an associate professor of endocrinology at Baylor College of Medicine in Houston, says that she thinks about multiple factors before prescribing GLP-1s for her patients 65 and older