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Doctors stress GLP-1s are most effective as part of a broader lifestyle change, and should not be used as a replacement for diet and exercise.

Recent data also strongly associate maternal postprandial hypoglycemia with adverse fetal outcomes, specifically a nearly two-fold increased risk of delivering a small-for-gestational-age (SGA) infant and higher rates of low birth weight

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There is some debate as to whether GLP-1 agonist drugs like Wegovy can lead to unhealthy muscle mass loss in addition to general weight loss