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Patience is key, as the medication works best when combined with lifestyle changes such as a healthy diet and regular physical activity

In this blog, we explore the evidence behind GLP-1 mental health side effects, how weight loss medications may alter your mood, and what to do if you are facing unpleasant psychological side effects

Report any of these warning signs to your healthcare provider immediately: persistently elevated blood sugar readings (above your target range for more than a few days), difficulty controlling hunger despite taking semaglutide, unexpected weight gain, or signs of infection (since prednisone suppresses immunity)

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats

However, the plausible actions of GLP-1RAs on several reward domains may require more nuanced interpretation

Zhang J, Sonnenburg D, Tric D, Kabisch S, Mari A, Theis S, Kemper M, Pivovarova-Ramich O, Rohn S, Pfeiffer AFH (2024) Isomaltulose Enhances GLP-1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose
