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Inadequate protein intake is particularly concerning, as it can contribute to muscle loss during weight reduction

I expect that there will be at least one arm of the phase 3 trials Lilly will run, and I suspect they may also try a 12mg arm and probably a 6mg arm as they tend to aim for 3 approved doses for weight loss indications

J Clin Endocrinol Metab 2023

She said she had been advised to just work on the calorie intake, not exercise As always, incredible insight

In terms of metabolic parameters, all the treated arms had beneficial changes in their HbA1c%, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, with the Sema+-MSTN+-ActA arm, which showed the largest combination of fat decrease and lean mass increase, showing the biggest beneficial changes (Fig

doi: 10.1097/mca.0000000000000830, PMID: [DOI] [PubMed] [Google Scholar] 13