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doi:10.2337/dc15-0169 Sorli C, Harashima SI, Tsoukas GM, et al

The STEP 4 trial [153] (ClinicalTrials.gov identifier: NCT03548987) was a 68-week, randomized, double blind, placebo- controlled trial of once-weekly subcutaneous semaglutide 2.4 mg or placebo for weight management in adults with obesity or overweight with type 2 diabetes

CER focusing on semaglutide versus other GLP-1 receptor agonists, SGLT2 inhibitors, and traditional therapies will help delineate its relative advantages and disadvantages, guiding clinicians in personalized treatment decision-making

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Together, these two pathways produce more pronounced appetite suppression and metabolic effects than either hormone alone