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Description
Compounds binding there can stabilise the active conformation without needing to mimic the full peptide-extracellular-domain interaction
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Additionally, tolerance can develop when the same medication dose is used long-term without adjustment
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Vildagliptin attenuates Huntingtons disease through activation of GLP-1 receptor/PI3K/Akt/BDNF pathway in 3-nitropropionic acid rat model
