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These features correspond to better initial responses to PD-1/PD-L1 inhibitors, although most patients ultimately develop resistance due to mechanisms such as activation of alternative checkpoints, reduced antigen recognition, T cell exhaustion, or metabolic dysregulation

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A liver-targeted structurally engineered fatty acid, icosabutate, potently reduces hepatic pro-fibrotic gene expression and improves glycemic control in an obese diet-induced mouse model of NASH

[DOI] [PubMed] [Google Scholar] 2.Pei L., Liu Y., Liu L., Gao S., Gao X., Feng Y., Sun Z., Zhang Y., Wang C

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