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It impacts the body's insulin levels, blood glucose (sugar) production, and hunger hormones, helping to regulate these elements in a way that promotes weight loss

28 Transport Routes Substances can cross the blood-brain barrier via paracellular transport and intercellular transport

Therefore, we think that declining of GLP-1 receptor expression in aorta in obese subjects may be involved in such high frequency of macrovascular complications

doi: 10.1016/S2468-1253(23)00011-0 76 YangLLiuGZhangYYaoBWuQPengLet al

[4] [5] The therapeutic effect is maintained through a combination of the drug still present in the system and its ongoing influence on glucose regulation mechanisms