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In a meta-analysis of 16 RCTs of adults with diabetes and CKD (four of which included people with type 1 diabetes), spironolactone added to standard therapy was associated with a reduction in 24 h urinary albumin/protein excretion [66]

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Testing these hypotheses merits future effort, as does reconsideration of the previous literature that has shown positive attributes of GIPR agonism for beta cell function 10,42,43

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