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| Sustained weight maintenance data | Limited | Yes (STEP 5, 104 weeks) | Tesofensine produces faster weight loss on a per-month basis, while semaglutide produces greater total weight loss over a longer treatment period and has demonstrated sustained results with continued use

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This rigid protocol frustrates some patients, particularly those managing diabetes or weight loss alongside multiple medications

However, its main purpose is glucose control rather than appetite suppression or significant weight reduction

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