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GLP-1 receptor agonists emerged from diabetes research and now represent a major advancement in weight management

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However, no direct comparisons have been made between semaglutide and other antidiabetic medications, including sodiumglucose cotransporter-2 inhibitors (SGLT2i), thiazolidinediones (TZD), and dipeptidyl peptidase-4 inhibitors (DPP-4i), regarding liver outcomes in patients with both NAFLD and T2D

Average weekly weight loss on semaglutide ranges from 0.52 lbs per week, depending on dose, adherence, diet, and individual metabolic factors

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