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Description
12,13 Modifications to prolong the half-life of GLP-1 RAs include sequence substitutions conferring resistance to DPP-4, along with acylation (liraglutide and semaglutide), covalent bonding to modified Ig fragment crystallisable domain (dulaglutide), or covalent bonding to albumin
Conway B, Miller RG, Costacou T, et al
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Support includes preclinical binge eating models showing efficacy of GLP-1 and analogues, evidence of altered GLP-1 levels in BED/BN, preliminary human data with abnormal eating
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His work has recently appeared in the Cut, HuffPost, the Washington Post, and the San Francisco Chronicle
