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The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful riskbenefit evaluation when prescribing GLP-1 RAs in high-risk individuals.

Retatrutide could become the biggest drug in history

GLP-1 weight-loss drugs like semaglutide have taken the world by storm, but some studies have raised concerns about side effects, including kidney injury and skeletal muscle wastage

In the recent SOUL trial, the GLP-1 drug reduced the risk of MACE by 14% over 4 years

But when appetite drops, protein often drops too and that can impact lean muscle, recovery, and energy

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