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Tirzepatide has shown greater average weight loss in head-to-head trials, but semaglutide is the longer-established option with years of real-world data and proven results
Individual response varies significantly regardless of medication selection
This does not mean the medication has stopped workingmetabolic adaptation is expected and usually breaks with dose adjustment, exercise changes, or dietary shifts
Clemmons DR (2016) Role of IGF binding proteins in regulating metabolism
The trade-off for the low price is simplicity: no berberine, no probiotic, so cravings tied to glucose swings may linger
& Weiss, J
