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Semaglutide also acts on GLP-1 receptors involved in appetite regulation and digestive function

eClinicalMedicine 75 , 102782 (2024)

Reality A common misconception is that semaglutide must be injected on a completely empty stomach to work

For patients with higher-risk factorssuch as significant gastrointestinal symptoms or known delayed gastric emptying simple precautions can reduce the risk

For individuals with severe obesity (BMI 40 kg/m or 35 kg/m with comorbidities) who have not achieved adequate weight loss with non-surgical methods, bariatric surgery represents an evidence-based option

[27] Until Phase 3 data are available and regulatory review is complete, the full clinical profile of retatrutide remains under investigation, and all findings should be interpreted with appropriate caution