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Some people find this feels "weaker" initially because the peak concentration is lower, even though the total weekly drug exposure is similar
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Benefits of Retatrutide Therapy Unprecedented Weight Loss Early phase trials (NEJM 2023) showed average weight loss of ~24% at 48 weeks, which rivals bariatric surgery outcomes

Zhang X, Zhao Y, Chen S, Shao H

Although these cases are rare, they are still clinically important

Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain

Duara, M
