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While obesity carries a profound broader societal burden, indirect costs were excluded from the present analysis for several reasons

When treatment ends abruptly, these appetite-regulating mechanisms reset within weeks

12,16 however, there is a lack of data comparing these GLP-1 RA outcomes versus other glucose lowering therapies

Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

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