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[DOI] [PubMed] [Google Scholar] 164.Markham A

The findings come as real-world data shows around half of people discontinue GLP-1 receptor agonist treatment within 12 months, and just months after NICE published quality standards recommending post-treatment support for at least one year

Others call it a waste of money

Retatrutide is attracting attention because it simultaneously targets: GLP-1 signaling GIP signaling Glucagon signaling This triple agonist model is important because each pathway may influence metabolism differently

Weight Regain After Stopping Treatment While GLP-1 treatments deliver sustained benefits during use, discontinuing them often leads to weight regain