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The Federal Circuit vacated the district court decision and invalidated the patent in August 2000

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GLP- 1 Receptor Agonists in Combination with Insulin The GLP- 1 receptor agonists have been shown to improve blood glucose control when used in conjunction with insulin, particularly basal insulin, and may be particularly useful in the treatment of advanced T2DM [108]

Boxed warning included for thyroid C-cell tumor risk based on animal studies