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combined with injections of tirzepatide, a drug used increasingly for weight loss

[3] In phase II clinical trials, such as those reported in peer-reviewed journals, mazdutide demonstrated significant efficacy, achieving 1014% body weight reduction in adults with obesity over 32 to 48 weeks

This is not a criticism

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A recent study on semaglutide specifically demonstrated that the medication reduces appetite while simultaneously increasing dopamine reward signaling in the brain, suggesting that it does not simply blunt pleasure but rather redirects it