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Intra-articular injection of C57Bl/6 mice with an adenovirus vector overexpressing active TGF- [86] or repeated in-articular injections of recombinant TGF- induced hyperplasia of synovium with increases in inflammatory immune cells, including macrophages [87]

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By the 12-week mark, patients may achieve a total weight loss of around 510%

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Pancreatic -Cell Hyperplasia and Hyperglucagonemia Due to a Glucagon Receptor Splice Mutation

Wegovy and Zepbound also have a more convenient dosing regimen as once-weekly injections, compared with Saxenda, which requires a daily injection